Abstract
SummaryProestrous serum LH and FSH levels and ovulation were significantly reduced when either γ-butyrolactone (GBL), which is hydrolyzed in vivo to the naturally occurring CNS depressant γ-hydroxybutyr-ate (GBH), or pimozide, a dopaminergic receptor blocker, was administered to 4-day cyclic rats just prior to the proestrous critical period. These data suggest that GBL and pimozide inhibit ovulation by decreasing the proestrous serum LH and FSH surges through effects on a central dopaminergic pathway.The authors would like to express their appreciation to J. Bell, J. Tracy, G. Cole, and K. Koch for excellent technical assistance.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.