Abstract
The above study has shown that monkey and rabbit eyes respond differently to moderately irritating surfactant solutions. In addition when these materials are used as test solutions, the cup-aspirator when used on rabbit eyes has proved to be better than the Draize procedure in predicting the damage that would occur in the monkey. These results, in view of known human experience, strongly suggest that direct instillation of moderately irritating substances into the rabbit eye is not a satisfactory method for predicting possible hazard, and that new procedures such as the cup-aspirator must be developed and used to enable toxicologists to predict the safety of these materials. Differences in species response were attributed to anatomical and physiological differences and to the effect of conjunctival irritation on corneal response. Further study of the qualitative and quantitative properties of specific ocular lesions produced in rabbits and monkeys will be necessary for further elucidation of these differences.
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