Abstract
As a basis for explaining a difference observed in the mean hemoglobin level of subjects in the United States and in London, Price-Jones 1 suggested that the motoring habits of American subjects may have produced a slow chronic poisoning by carbon monoxide, as a result of which the oxygen pressure is constantly being slightly reduced and the bone marrow is compensating for the useless carboxyhemoglobin by making more red cells and hemoglobin and producing a relative polycythemia. Nasmith and Graham 2 found that guinea-pigs living continuously in a dilute carbon monoxide atmosphere were able to increase the quantity of hemoglobin and the number of erythrocytes to compensate for the loss in oxygen-carrying capacity. This was confirmed by Egdahl, 3 who also noted a polycythemiain human subjects after repeated exposures to small or moderate amounts of carbon monoxide. Experiments by Sayers, Yant, Levy and Fulton 4 in which six men
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: JAMA: The Journal of the American Medical Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
