Abstract
The DNA content and DNase I and II activity in cardiac muscle were investigated in dogs with experimental myocardial infarction. The biochemical data were compared with morphological ones. The decrease of DNA content in the ligated artery area during the earliest stages of necrosis (in 3-7 hours after the operation) and an increase of DNA content in the region of myocardial infarction during the later period of necrosis and cicatrization were observed as well. By the end of the cicatrizing process the DNA amount almost reached the normal level. DNase I activity was decreased in comparison with that in the normal cardiac muscle. DNase II activity was found to increase in the infarction zone during the periods of connective tissue proliferation (the 6th—20th days).
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