Abstract
AbstractNarcotic dependence was established in male rats by continuous infusion of morphine given in increasing concentrations. Termination of the morphine infusion resulted in the reliable occurrence of body shakes. Narcotic drugs, morphine, fentanyl, and methadone, blocked withdrawal body shakes in a dose‐dependent manner. The butyrophenone neuroleptics, haloperidol, benperidol, and azaperone, were also effective in reducing withdrawal body shakes at doses that do not produce side effects. Trifluoperazine and chlorpromazine, two tricyclic neuroleptics were effective in reducing withdrawal shakes only at high doses that produced side effects. The anti‐withdrawal action of morphine, haloperidol, benperidol, and azaperone but not of chlorpromazine and trifluoperazine was antagonized by naloxone.
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