A comparison of autoimmunity and experimental allergic thyroiditis in Strain 2 and Hartley strain guinea pigs

Abstract

The response of Strain 2 guinea pigs to immunization with thyroid extract in complete adjuvant was compared with the response of the Hartley strain. The Strain 2 did not develop thyroiditis as frequently or in as great a degree as the Hartley strain. This difference in degree of thyroiditis between these two strains occurred consistently even when the animals were immunized with a wide range of doses of thyroid extract and of mycobacteria in adjuvant, and was independent of the strain origin of the antigen used for immunization. Although the Strain 2 made less thyroiditis than the Hartley strain, it made as much agglutinating antibody, and often as much delayed sensitivity as the Hartley strain. The genetic controls regulating autoimminity to the thyroid and production of thyroiditis appear to differ from those regulating production of experimental allergic encephalomyelitis.