Abstract
The group of couples defined as “unexplained infertility”is a common indication for different fertility interventions. This group includes those couples who do not achieve a clinical pregnancy after two years, despite normal findings in their evaluation which includes: endocrine profile, hysterosalpingogram, semen analysis and midluteal phase progesterone level. Since the definition of this group is per exclusion, it is composed of heterogenic etiologies for infertility. Nevertheless, as long as the basic problem is not well defined, this group carries a special therapeutic challenge, and there is a difficulty in determining the ideal fertilization protocol.
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