Abstract
The use of streptokinase (SK) to replace streptokinase/streptodornase ( SK SD ) in delayed hypersensitivity skin testing was evaluated in 325 patients. Sixty patients responded to SK SD (100 U of SK per 25 U of SD) and 36 to SK (375 U). Thirty-two responded to SK SD but not to SK, and eight responded to SK but not to SK SD . SK, at the dosage used, is not a suitable substitute for SK SD in delayed hypersensitivity testing. SD may be the more potent recall antigen. Perhaps more importantly is that of 250 positive responders to a recall-antigen battery consisting of SK SD , SK, Candida, Trichophyton, tetanus toxoid, purified protein derivative, and coccidioidin, 99.2% (248) would have been detected had the testing for SK and SK SD not been done.
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