A comparison between FOLFOX4 and DCF therapeutic regimen in the treatment of aged advanced gastric cancer

Abstract

Objective To compare the efficacy and toxicity between FOLFOX4 regimen(oxliplatin +CF + 5-FU) and DCF regimen (docetaxel + Cisplatin + 5-FU)for aged advanced gastric cancer. Methods Clinical data of 43 chemotherapy -naive aged patients with advanced gastric cancer were analyzed. Of the 43 patients ,19 patients were treated with FOLFOX4 regimen,24 patients were treated with DCF regimen. The patients in FOLFOX4 group received intravenous infusion of L- OHP(85 mg/m2)at day 1 ,bolus injection of 5 FU(400 mg/m2)at days 1 -2,and continuous intravenous infusion of 5 -FU (600 mg/m2)for 22 h at days 1-2;14 days as one cycle. The patients in DCF group received administration of docetaxel (75 mg/m2) at day 1,intravenous infusion of DDP (75 mg/m2) at days 1-3, and intravenous infusion of 5-FU (750 mg/m2) at days 1 -5 ;21 days as one cycle.After 2- 3 cycles of treatment,the remission rate ,time to disease progression (TTP) ,overall survival (OS)were compared. Results There were no statistic significance in RR,TTP,OS ,but the difference was statistical in myelosuppression. Conclusions FOLFOX4 regimen does not only have a good therapeutic effect as same as DCF but also the hematologic toxicities is better than DCF regimen. Key words: Stomach neoplasms; Myelosuppression