Abstract
AbstractA rapid, straightforward, and efficient method for the synthesis of racemic α‐aminonitriles has been developed. This one‐pot, three‐component Strecker reaction of carbonyl compounds, amines and trimethylsilyl cyanide (TMSCN) proceeds in excellent yields in the presence of a catalytic amount of zirconium oxychloride octahydrate (ZrOCl2⋅8 H2O) under solvent‐free conditions at room temperature. The protocol is particularly convenient for both aliphatic and aromatic aldehydes, as well as cyclic ketones, in combination with primary and secondary amines. This method is also highly chemoselective. Mild reaction conditions, excellent yields, high chemoselectivity, operational simplicity, the absence of tedious separation procedures, clean reaction profiles, high atom‐economy, as well as the inexpensive and environmentally benign catalyst are the key advantages of this protocol. This Strecker reaction has also been studied in the absence of any catalyst and proceeds with good yields. The overall outcomes of these reactions in the presence and absence of catalyst are compared in the present study.
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