Abstract
Summary Background To understand neuronal molecular changes in senile diabetes we established a rat senile diabetes model and analyzed transcriptome and proteome changes. Methods Wistar rats were fed a high sugar, high fat diet for 16 months to induce diabetes. Non-diabetic aged rats and young rats were used as controls. Transcript and protein levels in the liver were then analyzed by microarray and antibody arrays, respectively. Results Neuronal genes that were differentially expressed between senile diabetic rats, non-diabetic aged rats, and young rats were distributed across 12 pathways and 23 Gene Ontology (GO) clusters. Among them, 2267 genes were aging-related, 1230 genes were diabetes-associated, and 9 proteins might be associated with neurological disorders. Conclusion In this study, we investigated transcriptome and proteome changes in animal models, analyzed the impact of aging and diabetes on neuronal molecules, and confirmed the correlations. Our study provides support for further studies on mechanisms of neuronal diseases.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
