A Comparative Study to Evaluate Efficacy of Curcumin and Aloe Vera Gel along with Oral Physiotherapy in the Management of Oral Submucous Fibrosis: A Randomized Clinical Trial

Ashwini Nerkar Rajbhoj,Anagha Shete,Rucha Gore,Tejas Mukund Kulkarni,Mrinal Shete,Rashmi Sapkal

doi:10.31557/apjcp.2021.22.s1.107

Ashwini Nerkar Rajbhoj, Anagha Shete + Show 4 more

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https://doi.org/10.31557/apjcp.2021.22.s1.107

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Abstract

The aim of the study is to compare the efficacy of Curcumin gel with Aloe Vera gel when both the gel are supplemented along with oral physiotherapy in the management of OSMF. A study of parallel group trial design, using simple randomization technique, was conducted on confirmed cases of OSMF. Patients were divided into two groups, one group(30 patients) was given curcumin gel(Curenext) and other group (30 patients) aloe Vera gel (Aloe Vera 100% relief) and each group was asked to do same oral physiotherapy excercises supplementally. Follow-up was done for 6 weeks and patients were assessed on the basis of improvement in mouth opening and burning sensation at 2, 4, and 6 weeks. There was an improvement in both the parameters at subsequent visits, but the Aloe Vera gel showed better improvement than curcumin gel in burning sensation after 6 weeks of treatment which was highly statistically significant p < 0.01. Curcumin gel and Aloe Vera gel are effective in improving OSMF symptoms, but aloe Vera gel is more efficacious in burning sensation improvement without any side effects. Hence, we can advocate these drugs as adjuvant treatment in addition to the recommended treatment.

Highlights

Oral Sub mucous Fibrosis (OSMF) is defined as an insidious, chronic disease that affects any part of the oral cavity and sometimes the pharynx (Pindborg and Sirsat, 1966)
Aim: The aim of the study is to compare the efficacy of Curcumin gel with Aloe Vera gel when both the gel are supplemented along with oral physiotherapy in the management of OSMF
Curcumin gel and Aloe Vera gel are effective in improving OSMF symptoms, but aloe Vera gel is more efficacious in burning sensation improvement without any side effects

Summary

Introduction

Oral Sub mucous Fibrosis (OSMF) is defined as an insidious, chronic disease that affects any part of the oral cavity and sometimes the pharynx (Pindborg and Sirsat, 1966). Plants have been a major source of medicine since the time immemorial (Lai et al, 1995). It has been documented in the literature that many incurable oral diseases when treated with alternative medicine therapy such as Ayurveda have shown good prognosis (Lai et al, 1995). Aloe Vera is one such Ayurvedic treatment drug for OSMF (Sudarshan et al, 2012a). The polysaccharides that are present in the Aloe Vera leaves have wound healing, anti-inflammatory, anticancer, immunomodulatory as well as gastro-protective properties. It is found to have soothing and cooling properties (Sudarshan et al, 2012a)

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