A Comparative Study to Ascertain the Efficacy of Palonosetron, Granisetron and Metoclopramide in Preventing Post-Operative Nausea and Vomiting in Patients Undergoing General Anaesthesia for Ear, Nose and Throat Surgeries

Dr Jasmine Kaur,Dr Farah Husain

doi:10.34257/gjmrivol20is1pg11

Abstract

Postoperative nausea and vomiting (PONV) can be a very distressing side effect following general anaesthesia. Patients and health care professionals report the avoidance of PONV is of equal or sometimes even greater concern than avoidance of postoperative pain.1 It can result in increased morbidity, delay in hospital discharge and unexpected hospital re-admission, thereby increasing the total medical costs2. Moreover, PONV has been a major cause of decreased patient satisfaction3. There are several physiologic complications of nausea and vomiting that are of concern to the anaesthesiologist. Some of them being visceral wound dehiscence, electrolyte disorders, raised venous pressure leading to bleeding, rise in intraocular and intracranial tension and aspiration pneumonia especially in the sedated post-operative patient.

Highlights

Postoperative nausea and vomiting (PONV) can be a very distressing side effect following general anaesthesia
PONV has been a major cause of decreased patient satisfaction[3]
Some of them being visceral wound dehiscence, electrolyte disorders, raised venous pressure leading to bleeding, rise in intraocular and intracranial tension and aspiration pneumonia especially in the sedated post-operative patient

Summary

Introduction

Postoperative nausea and vomiting (PONV) can be a very distressing side effect following general anaesthesia. Patients and health care professionals report the avoidance of PONV is of equal or sometimes even greater concern than avoidance of postoperative pain.1It can result in increased morbidity, delay in hospital discharge and unexpected hospital readmission, thereby increasing the total medical costs[2]. The risk and postoperative pain.1It can result in increased morbidity, incidence of PONV increases with post-operative opioid delay in hospital discharge and unexpected hospital re- use[3] but has been found to be decreased in smokers as admission, thereby increasing the total medical costs. Some of them being abdominal specially gastro intestinal, laparoscopic visceral wound dehiscence, electrolyte disorders, raised surgeries, ENT surgeries and ophthalmic surgeries are venous pressure leading to bleeding, rise in intraocular more likely to lead to PONV because of stimulation of and intracranial tension and aspiration pneumonia vagal afferents during manipulation.[5] especially in the sedated post-operative patient

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Discussion

Conclusion