Abstract
BackgroundThe electrical signals measuring method is recommended to examine the relationship between neuronal activities and measure with the event related potentials (ERPs) during an auditory and a visual oddball paradigm between schizophrenic patients and normal subjects. The aim of this study is to discriminate the activation changes of different stimulations evoked by auditory and visual ERPs between schizophrenic patients and normal subjects.MethodsForty-three schizophrenic patients were selected as experimental group patients, and 40 healthy subjects with no medical history of any kind of psychiatric diseases, neurological diseases, or drug abuse, were recruited as a control group. Auditory and visual ERPs were studied with an oddball paradigm. All the data were analyzed by SPSS statistical software version 10.0.ResultsIn the comparative study of auditory and visual ERPs between the schizophrenic and healthy patients, P300 amplitude at Fz, Cz, and Pz and N100, N200, and P200 latencies at Fz, Cz, and Pz were shown significantly different. The cognitive processing reflected by the auditory and the visual P300 latency to rare target stimuli was probably an indicator of the cognitive function in schizophrenic patients.ConclusionsThis study shows the methodology of application of auditory and visual oddball paradigm identifies task-relevant sources of activity and allows separation of regions that have different response properties. Our study indicates that there may be slowness of automatic cognitive processing and controlled cognitive processing of visual ERPs compared to auditory ERPs in schizophrenic patients. The activation changes of visual evoked potentials are more regionally specific than auditory evoked potentials.
Highlights
The electrical signals measuring method is recommended to examine the relationship between neuronal activities and measure with the event related potentials (ERPs) during an auditory and a visual oddball paradigm between schizophrenic patients and normal subjects
The ERPs provide a means of measuring the cognitive processing that is independent of the motor speed and disability and reflects processes that occur between the stimulus and the response; the ERPs provide the information about their courses [9,10]
The aim of this study is to assess whether the visual ERPs can be a clinically effective diagnostic tool to be used for differentiation of schizophrenic patients or not
Summary
The electrical signals measuring method is recommended to examine the relationship between neuronal activities and measure with the event related potentials (ERPs) during an auditory and a visual oddball paradigm between schizophrenic patients and normal subjects. The aim of this study is to discriminate the activation changes of different stimulations evoked by auditory and visual ERPs between schizophrenic patients and normal subjects. Evoked potentials from different stimulations are assumed to reflect the anatomical and functional differences between the auditory and the visual pathways. Some meta-analytical studies strongly confirm the existence of ERP deficits in schizophrenia. The ERPs provide a means of measuring the cognitive processing that is independent of the motor speed and disability and reflects processes that occur between the stimulus and the response; the ERPs provide the information about their courses [9,10]
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