A comparative study on fatty acid profile in selected vessels of coronary artery bypass graft (CABG).

E M S Bandara,A G Jayakrishan,H D Waikar,S K Sharma,L G Chandrasena,P P R Perera,H Peiris,D I U Edirisinghe,V Abeysuriya,D D C De S Wanniarachchi,Michinari Nakamura

doi:10.1371/journal.pone.0260780

E M S Bandara, A G Jayakrishan + Show 9 more

Open Access

https://doi.org/10.1371/journal.pone.0260780

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Journal: PloS one	Publication Date: Jan 21, 2022
Citations: 1	License type: CC BY 4.0

Affiliation: University of Sri Jayewardenepura

Abstract

Atherosclerosis is one of the leading non-communicable diseases in Sri Lanka. Analysis of fatty acid composition in blood vessels is important in understanding the development of atherosclerosis. Here, analyses of fatty acid profiles in major arteries which are commonly used in Coronary Artery Bypass Graft surgery (CABG) were subjected to investigation. Patients (n = 27) undergoing elective CABG were enrolled in the study. A small biopsy segment of the saphenous vein (SV), radial artery (RA), and left internal mammary artery (LIMA) of patients was obtained during the surgery. The fatty acid (FA) profile of tissue samples was analyzed using Gas Chromatography-Mass Spectroscopy (GCMS). Among the different arteries tested, palmitic acid and stearic acid were the predominant fatty acids. As far as monounsaturated FA (MUFA) are concerned, oleic acid was found to be the most abundant MUFA in vessels. The FA profile of LIMA samples had a higher SFA percentage and lower unsaturated FA percentage compared to other vessels. Furthermore, the vessel samples of RA indicated the highest percentage of pro-inflammatory ω -6 polyunsaturated fatty acids (PUFA) as well as a higher percentage ratio between ω -6: ω -3 PUFA. The fatty acid composition and ω -6: ω -3 PUFA ratio suggests that LIMA graft is preferred for CABG over RA and SV.

Highlights

Ischemic heart disease is the leading cause of death worldwide [1]
The majority of patients receive left internal mammary artery (LIMA) grafts to the left anterior descending (LAD) coronary artery compared to other grafting options such
The present study reports the comparison of the fatty acid composition of three biopsy specimens of three important vessels collected during coronary artery bypass grafting (CABG), namely LIMA, radial artery (RA), and saphenous vein (SV) for the first time in literature

Summary

Introduction

Ischemic heart disease is the leading cause of death worldwide [1]. The success of coronary artery bypass grafting (CABG) which is one of the common surgical techniques used to improve the blood flow in the heart is dependent on the long-term patency of arterial and venous grafts [2]. The majority of patients receive left internal mammary artery (LIMA) grafts to the left anterior descending (LAD) coronary artery compared to other grafting options such. A comparative study on FA profile in selected vessels of CABG

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