A comparative study of ziprasidone and clozapine on efficacy and executive function in treatment of schizophrenia

Abstract

Objective To evaluate the efficacy and safety and to study the effect on executive function of ziprasidone in treatment of schizophrenia. Methods A total of 84 schizophrenic inpatients were randomly divided into study group treated with ziprasidone(n = 42 ) and control group treated with clozapine (n = 42 ) for 12 weeks treatment. Positive and negative syndrome scale (PANSS) and treatment emergent symptoms scale (TESS) were used to evaluated the efficacy and the side effects before and in the end of 4th ,Sth, 12th week. Wisconsin Card Sor-ring Test were used to evaluated executive function before and in the end of 12th week. Results After treatment, the scores of PANSS reduced significantly than those before treatment in two groups. (P<0.05 or P<0.01). The side effects in study group were significantly fewer than those in control group. (P <0.05 or P <0.01 ). The total number, persistent error number and random error number in study group were significantly better than those in control group. (57.58±14.01 vs 67.51±20.99;14. 11±7.42 vs 18.05±5.49;17.43±8.68 vs 24.34±7.61, P<0.05 or P<0.01). Conclusion Ziprasidone were effective and less side effects in the treatment of schizophrenia. Executive function in study group were significantly better than those in control group. Key words: Ziprasidone ; Clozapine ; Schizophrenia ; Efficacy ; Executive function ;