A comparative study of two porous sponge scaffolds prepared by collagen derived from porcine skin and fish scales as burn wound dressings in a rabbit model.

Dan Zhao,Hongjian Zhang,Jun Ma,Xin Zhang,Yufei Shi,Zhan Chen

doi:10.1093/rb/rbz036

Dan Zhao, Hongjian Zhang + Show 4 more

Open Access

https://doi.org/10.1093/rb/rbz036

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Abstract

Collagen is widely used in biomedical applications due to its outstanding properties. In this study, highly porous sponge scaffolds were developed by using porcine skin-derived collagen (PSC) and fish scale-derived collagen (FSC), respectively. The morphology and composition of these PSC and FSC scaffolds were compared. The water uptake ratio of FSC scaffolds reached 47.8, which is 1.7 times of PSC scaffolds. The water vapour transmission rates (WVTR) of PSC and FSC scaffolds were 952.6 ± 55.5 and 1090.9 ± 77.1 g/m2/day, which could produce a moist healing environment for wounds. Both scaffolds show non-toxicity to L929 fibroblast cells. The burn wound healing efficiency of these two scaffolds was examined in vivo using rabbits. No scars around the wounds were observed after applying PSC and SFC scaffolds. Histopathological studies reveal that the wound treated with PSC and FSC scaffolds showed much better wound recovery than gauze and vaseline gauze groups. It was suggested that FSC scaffolds have great potential as same as PSC to be used as burn wound dressing materials.

Highlights

The global market for the management of wounds and burns is very huge, including conventional wound dressings and advanced wound dressings [1,2,3]
The obtained solution of porcine skin-derived collagen (PSC) seemed thinner than the fish scale-derived collagen (FSC) solution
Nanofibers prepared by electrospinning could be applied to collagen-based materials, and advanced wound dressings composed of nanofibers have been developed as controlled delivery system for drugs and growth factors [27,28,29]

Summary

Introduction

The global market for the management of wounds and burns is very huge, including conventional wound dressings and advanced wound dressings [1,2,3]. Wound healing involves four stages including haemostasis, inflammatory, proliferation and remodelling in order [3]. A suitable moist environment around the wounds is important to the regeneration of skin tissues and healing process. Conventional wound dressing such as cotton gauze show limited recovery effects in burn management as they could not provide a suitable moist environment for wound healing [1, 2]. Burn wounds result in severe inflammatory responses and often cause serious secondary injuries when using conventional wound dressings [3]

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