Abstract
Summary 1.More than 1,000 cases of whooping cough have been treated, of which 432 could be carefully followed through the disease; 80 patients served as controls. 2.Curves of average frequency of coughing spells in twenty-four-hour periods, as well as careful division of cases into “excellent,” “good,” “fair,” and “poor” results of treatment, have been used to determine the efficacy of treatment. 3.Vaccine therapy, whether with Krueger's vaccine, Sauer's vaccine, toxin vaccine, or Bordet vaccine, not only did not ameliorate the symptoms but actually produced curves above those of the control cases. 4.Results obtained with nasal topagen and with soluble topagen hypodermically did not differ materially from the untreated controls. 5.Cases treated with convalescent serum and with hyperimmune serum showed fewer coughing spells, a shorter period of illness, and greater freedom of complications. These results could only be obtained when the serum was injected before the paroxysmal stage of the disease. Summary 1.More than 1,000 cases of whooping cough have been treated, of which 432 could be carefully followed through the disease; 80 patients served as controls. 2.Curves of average frequency of coughing spells in twenty-four-hour periods, as well as careful division of cases into “excellent,” “good,” “fair,” and “poor” results of treatment, have been used to determine the efficacy of treatment. 3.Vaccine therapy, whether with Krueger's vaccine, Sauer's vaccine, toxin vaccine, or Bordet vaccine, not only did not ameliorate the symptoms but actually produced curves above those of the control cases. 4.Results obtained with nasal topagen and with soluble topagen hypodermically did not differ materially from the untreated controls. 5.Cases treated with convalescent serum and with hyperimmune serum showed fewer coughing spells, a shorter period of illness, and greater freedom of complications. These results could only be obtained when the serum was injected before the paroxysmal stage of the disease.
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