Abstract
The regulation of the function of adrenal zona glomerulosa appears to be under the control of several factors, ACTH being an important one among them. Recent studies using crude posterior pituitary extract and purified vasopressin have shown that these preparations cause significant stimulation of mitotic activity of female rat adrenal zona glomerulosa. The mitogenic activity is very evident with the hypophysectomized animal model in which 2 days of treatment with vasopressin causes almost complete restoration of mitotic activity while ACTH is only weakly effective. Vasopressin also increases the plasma aldosterone in the normal animal in a manner comparable to ACTH in terms of dose response and time course for short-term treatment. In long-term treatment vasopressin also increased the plasma aldosterone while ACTH did not cause a significant change. A similar pattern was observed for plasma corticosterone. The lack of increment of plasma aldosterone to vasopressin in hypophysectomized animals indicates that the observed in vivo steroidogenic effect in intact animals is probably mediated through other factors.
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