Abstract
A comparative study of the activity and age-dependent inducibility of creatine phosphokinase of rat cardiac muscle has been presented. The specific activity of creatine phosphokinase (CPK) is higher in young (7-week) than in the adult (30-week) and old (80-week) rats. Adrenalectomy decreases the activity of CPK of young and old rats, but not of adult rats. Both cortisol and cortisone induce the enzyme significantly in young and old rats. The magnitude of induction is higher in the old than in the young. Both the hormones decrease the activity of CPK in the adult cardiac muscle. The induction by the hormones is repressed by actinomycin D. The above findings have been discussed in relation to deterioration of the cardiac function during aging of the animal.
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