Abstract
The authors established the quantitative fixation of chlortetracycline, tetracycline, and oxytetracycline by homogenates of the liver, kidneys, spleen, lungs, heart, and brain of white rats. Fixation by the organ homogenates was greatest by chlortetracycline, followed by tetracycline and oxytetracycline in that order. Homogenates of the liver, kidneys, and brain fixed the tetracyclines in considerable quantitities, those of the lungs, heart and spleen—to a noticeably lesser degree.
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