Abstract
AbstractA rat open field test is described in which the inherent tendency of rats to explore an environment is titrated against their inherent tendency to avoid an open field that is large, brightly illuminated, ceilingless, and novel. The procedure appeared responsive to the effects of benzodiazepines, barbiturates, and some related compounds. Particularly pronounced activity was obtained with ritanserin; the compound disinhibited rat exploratory behavior at doses ranging from 0.04 to 10 mg/kg. Ritanserin, but not chlordiazepoxide, significantly increased the number of animals entering the open field. Chlordiazepoxide, but not ritanserin, significantly increased the number of animals making at least nine transits. The observations suggest that chlordiazepoxide and ritanserin differ in their mode of disinhibitory action on rat open field behavior.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
