Abstract
Carbonated drinks are widely consumed because of their taste and their ability to refresh and quench thirst. These carbonated drinks also exist in the form of diet drinks, for example Diet Coke®, Pepsi®, extra. A comparative effect of the diet and regular soda carbonated drinks on the histology of the cerebellum of female albino Wistar rats was investigated. Fifteen adult female Wistar rats weighing between 180-200 g were divided into 3 groups; designated as groups A, B and C, and each group consisted of five rats. Group A was the Control group and received distilled water, while groups B and C were the experimental groups. Group B was administered 50 ml of regular soda (RS), and group C was administered 50 ml of diet soda (DS) each per day for 21 days, and the rats were sacrificed on Day 22, and their cerebellums excised and preserved. Histological result of the sections of the cerebellum showed shrunken and degenerated Purkinje cells with hypertrophied dendrites, especially in the DS group, which was less in the RS group compared to the control group. These results suggest that diet soda has adverse effect on the cerebellum of adult female albino Wistar rats.
Highlights
Carbonated drinks elicit a sensation that is highly sought after, yet the underlying neural mechanisms are ill defined
Diet coke® (DC) on the other hand is a non-caloric beverage that is sweetened with aspartame, except for the splendor-sweetened version, which is sweetened with both splendor, or sucralose, and acesulfame potassium, and which is known as Ace K3, 4
As most of the previous studies were concerned about the effect of aspartame on memory, learning and behavioral changes, this study investigates the effect of aspartame and nonaspartame products on the histology of the cerebellar cortex of adult female albino Wistar rats
Summary
Carbonated drinks elicit a sensation that is highly sought after, yet the underlying neural mechanisms are ill defined. Diet coke® (DC) on the other hand is a non-caloric beverage that is sweetened with aspartame, except for the splendor-sweetened version, which is sweetened with both splendor, or sucralose, and acesulfame potassium, and which is known as Ace K3, 4. Objectives: A comparative effect of the diet and regular soda carbonated drinks on the histology of the cerebellum of female albino Wistar rats was investigated. Conclusions: These results suggest that diet soda has adverse effect on the cerebellum of adult female albino Wistar rats.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
