A comparative study of stem cells between the mucosa of inferior turbinate and nasal polyps by nestin marker using immunhistochemical technique

Abstract

Nasal polyps are mucosal lesions raised from paranasal sinuses as a response to infectious or inflammatory stimuli. From histological view, nasal polyps had thick and proliferative epithelial mucosa. Stem cells are originator cells; liable for regeneration of cells. Nestin is an intermediate filament protien expressed in progenitor cells and play a major role in tissue regeneration. Nestin immunoreactive-positive cells (stem cells) was higher in mucosal epithelium of nasal polyp compare with mucosal epithelium of normal nasal inferior turbinate signify that stem cell may have specific role in nasal polyp formation.