Abstract
“Carbicarb” (CBC; International Medication Systems, South El Monte, CA) is a new alkalinizing agent composed of equimolar NaHCO 3 and NasCO 3, each salt 1 3 mol/L in concentration. We compared CBC with 1 mol/L NaHCO 3 in the treatment of lactic acidosis in dogs with hemorrhagic shock. Carbon dioxide excretion from the lungs (CO 2 output), along with arterial and mixed venous PCO 2, increased significantly less with CBC than with NaHCO 3 for 30 minutes following therapy. Arterial pH increased more with CBC than with NaHCO 3 for the first five minutes of therapy. Both alkaline solutions produced increases in mean arterial pressure, cardiac output, oxygen delivery, and oxygen consumption. These increases were not significantly different for the two solutions. CBC injection did not result in any damage to RBCs or to the endothelium of peripheral veins.
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