A Comparative Study of Severity of Covid-19 Infection & their Radiological Findings in Vaccinated and Unvaccinated Individuals

Abstract

Objectives: To compare the severity of COVID-19 infection and their radiological findings between vaccinated and unvaccinated individuals. Also, to investigate if any difference of severity of infection exists between patients with blood group ‘A’ and with blood group ‘O’. Methods: This study has 302 patients which include both vaccinated and unvaccinated individuals. Both the group of patients were subjected to Computed tomography-Chest imaging and the severity of COVID-19 infection was analyzed between both the groups using CT-Severity score (CT-SS). Findings: In 302 study population, 91% of patients are unvaccinated and remaining 9% are vaccinated. Among these patients, 273 were having CORADS-5 which constitute 90% of population. Mortality among unvaccinated people was 17.2% compared to vaccinated people having mortality rate of 3.4% which was significant. Individuals with Blood group ‘A’ were highly infected and individuals with group ‘O’ were least affected compared to individuals with other blood groups among unvaccinated individuals. Novelty: Increased mortality was seen among unvaccinated individuals( 17.2%)compared to vaccinated patients(3.4%). CT-Severity score was lower among vaccinated patients compared to unvaccinated patients. This study also compared the severity of the infection in individuals with various ABO blood groups among unvaccinated patients which showed that there was a significant effect on blood groups on severity of infection. Keywords: COVID19; Vaccination; CTSeverity score; ABO Blood grouping; Mortality