A Comparative Study of Serum Uric Acid Level in First Degree Relatives of Patients of Acute Coronary Syndrome and In Normal Subjects

Abstract

1 Demonstrator, Department of Physiology, Assam Medical College, Dibrugarh-786002, Assam, India 2 Professor, Dept of Physiology, Fakhruddin Ali Ahmed Medical College, Barpeta-781301, Assam, India 3 Professor, Department of Cardiology, Assam Medical College, Dibrugarh-786002, Assam, India Corresponding Author Dr Subha Bhakta Department of Physiology, Assam Medical College, Dibrugarh, Assam-786002 Email: subha84b@gmail.com , Mobile no: 9435678993 ABSTRACT Background: Ischaemic heart disease (IHD) is a leading cause of worldwide morbidity and mortality. A number of risk factors have been described in the etiology of IHD. Uric acid is one of the modifiable risk factor plays a role in the development of cardiovascular morbidity in the general population. We can delay the development of IHD by better control of uric acid levels in first degree relatives (FDRs) of IHD patients. We conducted a study in which we were assess serum uric acid levels independent of other established risk factors in FDRs of IHD patients and in normal subjects. Method: Sixty first degree relatives of IHD patients were selected, who were the attendants of the patients coming to the cardiology OPD and patients admitted to Intensive Care Unit (ICU), Assam Medical College Dibrugarh. An equal number of subjects were selected as a control group who had no family history of IHD. After a detailed clinical history and physical examination, fasting blood samples were collected. Blood glucose, lipid profile and serum uric acid levels were estimated. Results: The serum uric acid levels were found to be significantly high in first degree relatives of acute coronary syndrome in comparison to healthy individuals. Conclusion: . We therefore conclude that high uric acid has a definite role in Cardiovascular disease in first degree relatives.