Abstract
Background: Preeclampsia is associated with liver function abnormalities and renal function impairment. The objective of this study is to compare serum uric acid, glucose, calcium and magnesium in pre-eclampsia with normal pregnancy. Materials and Methods: Normal pregnant women and pre eclamptic women of age group 20-40 years were included. Serum magnesium, calcium, glucose, uric acid were analyzed.Results: Mean serum magnesium level in preeclampsia (1.83 ± 0.21mg/dl) was lesser in comparison to normal pregnant women (2.03 ± 0.16 mg/dl). Serum calcium level was lower (8.10 ±0.56mg/dl) than control (9.59 ±0.62 mg/dl) with p<0.001. Uric acid, glucose and lactate dehydrogenase in preeclamptic women was significantly higher than that in normal pregnant women (6.14 ± 0.85 vs.4.01 ± 0.62, p=<0.001), (94.17± 18.65 vs.86.34 ± 10.19, p=0.033) and ( 466.80 ± 97.29 vs. 194.22 ± 39.76, p=<0.001) respectively.Conclusion: There were significant changes in serum magnesium, uric acid, calcium, glucose, lactate dehydrogenase and total protein in pregnant women.
Highlights
Preclampsia, a systemic syndrome of pregnancy is clinically characterized by new onset of proteinuria and hypertension after 20 week of gestation and is associated with significant morbidity and mortality to both mothers and fetuses
Comparison of the clinical characteristics and symptoms for group of participants are shown in the Table 1. 60% of the case in preclampsia was nulliparous with period of gestation 35.91 week
The mean systolic blood pressure recorded in preclampsia was 144 ±11.93 which was statistically significant (p
Summary
Preclampsia, a systemic syndrome of pregnancy is clinically characterized by new onset of proteinuria and hypertension after 20 week of gestation and is associated with significant morbidity and mortality to both mothers and fetuses. The results from many clinical studies show the relationship between the aggravation of the hypertensive complication and the change in concentration of various chemistries in mother’s serum.[1,6] The development of preclampsia in patients with gestational diabetes mellitus has been reported.[12] In preclamptic women, plasma insulin fasting insulin resistance Index (FIRI), calculated from fasting insulin and glucose concentration have been found significantly higher than the baseline value from 20 and 24 weeks respectively.[13] In gestational diabetes mellitus (GDM) patients having higher blood pressure readings early in pregnancy, even prior to GDM diagnosis, were associated with the subsequent development of preclampsia.[12] Hypocalcemia, hypomagnesaemia and hyperuricemia seen in serum need to be correlated for sever preclampsia.[14,15] Interestingly, variable serum calcium, magnesium and uric acid are found in preclamptic mothers.[1,7,16]. The objective of this study is to compare serum uric acid, glucose, calcium and magnesium in preclampsia with normal pregnancy
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