A Comparative Study of Serum Lipid Profile in Patients with Oral Squamous Cell Carcinoma and Healthy Population in a Tertiary Health Care Centre in North-Western India

Abstract

Aims and Objectives: The aim of the study was to study serum lipid profile in patients with oral squamous cell carcinoma (OSCC) and to compare their levels with those of healthy population. Materials and Methods: This study was done in forty five patients of Oral Squamous Cell Carcinoma and the results were compared with results of forty five age and sex matched healthy controls . Serum obtained from centrifugation of 12 hour fasting blood samples was analyzed on fully automated analyzer Beckman coulter AU-680 for estimating the lipid levels (cholesterol, triglycerides [TGL], and high-density lipids [HDL]) by colorimetric method. Low-density lipid [LDL] values were obtained by calculator. Results: The comparison of lipid profile levels between Oral Squamous Cell Carcinoma cases and healthy controls shows statistically significant results for TC, HDL and LDL. Conclusion: The change in lipid levels may have an early diagnostic or prognostic role in oral malignant lesions and can be used as a biomarker for OSCC patients.