Abstract
Introduction: Blood is the gold standard body fluid for diagnosis of Diabetes Mellitus (DM) but saliva can offers an alternative to serum as a biological fluid for diagnostic purposes because it contains serum constituents. People wants that medical science should promote non invasive method for diagnosis of disease.
 Aim: The study was conducted to estimate and compare serum and salivary glucose, total protein, calcium and phosphorus levels in DM type ll and healthy subjects and to evaluate whether saliva can be used as a diagnostic fluid in DM type ll patients. The target population of this study was individuals who have Type-2 DM for different period of time and resident INDORE.
 Materials & Methods: Study consisted of 50 subjects from OPD/IPD Index Medical College & Research Center, INDORE, MADHYA PRADESH, India. The study groups were divided into Group I-25 DM patients (TypeII) and Group II-25 healthy subjects. The saliva and serum samples were collected from each subject and levels of different biochemical parameters were estimated.
 Result: were noted. On comparing values in saliva and serum, among two groups, a significant difference (p<0.005) was found between few of them.
 Conclusion: Values regarding blood and salivary biochemical parameters were distinctly different between two groups suggesting salivary parameters can be used as a diagnostic alternative to blood parameters for diabetes mellitus.
Highlights
Introduction: Blood is the gold standard body fluid for diagnosis of Diabetes Mellitus (DM) but saliva can offers an alternative to serum as a biological fluid for diagnostic purposes because it contains serum constituents
Aim: The study was conducted to estimate and compare serum and salivary glucose, total protein, calcium and phosphorus levels in DM type ll and healthy subjects and to evaluate whether saliva can be used as a diagnostic fluid in DM type ll patients
This study aimed to evaluate salivary and serum glucose, total protein calcium& phosphorus levels in adult patients with T2D compared with healthy controls and to determine the correlation of salivary biomarkers with blood biomarkers in both diabetic patients and healthy controls
Summary
Type II Diabetes mellitus is an endocrine disease characterized by a short fall in the production of insulin with consequent alteration of process of assimilation, metabolism and balance of blood glucose concentration which when left untreated can lead to serious complications(1). Saliva is an accessible clinical sample that has been in the spotlight of the researchers’ attention due to its possession of different enzymes, molecules and distinctive function in the diagnosis and treatment of various diseases.(5) Saliva has been put forth as a potential diagnostic tool for surveillance of disease due to its several advantages It clearly offers an inexpensive, simple and easy to use screening methods.(6). This study aimed to evaluate salivary and serum glucose, total protein calcium& phosphorus levels in adult patients with T2D compared with healthy controls and to determine the correlation of salivary biomarkers with blood biomarkers in both diabetic patients and healthy controls
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