Abstract
Background: The aim of this study was to study the complications and to compare the effects of the antiemetic premedication on incidence of nausea and vomiting induced by sub-arachnoid bupivacaine and calcitonin. Material and Method: In a prospective, double-blind, randomized sequential allocated study, 80 ASA I and II physical status patients received 0.5% bupivacaine with 100 i.u salmon calcitonin in sub-arachnoid space and were divided into four groups of 20 each. Group I received chlorpromazine, Group II received dexamethsone, Group III received Granisetron, and Group D received no antiemetic as premedication. Results and Conclusion: The incidence of postoperative nausea vomiting is highly variable following subarachnoid blockade with a further increase in incidence observed upon addition of additives to increase the duration of analgesia. Granisetron is a potent antiemetic among dexamethsone and chlorpromazine for prevention of postoperative nausea vomiting.
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