A comparative study of one-step and two-step approach in establishing 5/6 nephrectomy model of renal failure

Abstract

Objective To compare the effect of one-step and two-step approach in establishing 5/6 nephrectomy model of renal failure. Methods One-step and two-step approach were used to establish the model of 5/6 nephrectomy, and the mortality rate and the levels of creatinine and urea nitrogen were recorded in the two groups at the end of week 4, week 8 and week 12 after the operation. Results The mortality rate was 17.65% in the one-step group at the end of the 4th week, compared with 29.41% in the two-step group at the same time after the operation. The renal failure models were successfully established in the two groups, and there was no significant difference in the levels of creatinine and urea nitrogen between the two groups at the end of the 8th week. Conclusion One-step and two-step approach can successfully establish 5/6 nephrectomy model of renal failure, and the one-step approach may produce lower mortality. Key words: 5/6 Nephrectomy; Renal failure