Abstract
Objective: To compare efficacy, safety and tolerance of combination of Mifepristone and Misoprostol versus Misoprostol alone in induction of labour in late intrauterine fetal death (>24 weeks).
 Methods: This prospectively study included 160 women with late intrauterine fetal death (IUFD) after 24 weeks of gestation and divided the women randomly into two groups each containing 80 women. In Group-A : Mifepristone 200 mg single dose was given and after 24 hrs Tab Misoprostol (intravaginally) administered and repeated 4 hourly upto a maximum of 5 doses, while in Group-B : Only Tab Misoprostol administered intravaginally 4 hourly upto maximum 5 doses. Induction-delivery interval and number of doses of Misoprostol was calculated. 
 Results: The mean induction-delivery interval in Group-A was 13.02 ± 3.74 hours and in Group-B was 16.09 ± 2.99 hours (p-value <0.0001). Mean doses of Misoprostol required in Group-A was 3.36 ± 1.08 hours and in Group-B was 4.32 ± 0.65 hours (p-value <0.0001).
 Conclusion: Combination of Mifepristone and Misoprostol is more effective as comparison to Misoprostol in terms of induction-delivery interval and number of doses of misoprostol required. 
 Keywords: IUFD, mifepristone, misoprostol, induction of labour, induction-delivery interval.
Highlights
The frequency of intrauterine fetal death with a retained fetus varies, but is estimated to occur in 1% of all pregnancies
Combination of Mifepristone and Misoprostol is more effective as comparison to Misoprostol in terms of induction-delivery interval and number of doses of misoprostol required
A study conducted by Modak R et al (2018)[5] in which mean doses of misoprostol required in Group-I (Mifepristone and Misoprostol) was 2.41 ± 1.19 and in Group-II (Misoprostol only) was 3.67 ± 1.07
Summary
The frequency of intrauterine fetal death with a retained fetus varies, but is estimated to occur in 1% of all pregnancies. It is of utmost important to search for the method which can reduce hour of pain in labor of IUFD cases.[2] moderate to severe maternal anxiety had been found to occur if labor has failed to start 24 h after diagnosis. Mifepristone if administered before Misoprostol sensitizes the uterus to the action of prostaglandins and ripens the cervix Due to this effect of Mifepristone on the cervix, lower doses of Misoprostol are required to induce expulsion of fetus. This present study was undertaken to compare the effectiveness and safety of combination regime of mifeprostone and misoprostol with misoprostol alone. The aim of present study is to compare the efficacy and safety of combination of Mifepristone and Misoprostol versus misoprostol alone
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
