Abstract
Background: Hypertension is recognized as most common cardiovascular disorder and a leading cause of morbidity and mortality worldwide. There is abnormal lipid peroxidation which suggested that oxidative stress is important in the pathogenesis of hypertension. This study aims at understanding the role of oxidative stress in hypertension.
 Aim of the Work: The objective of this study was to determine the malondialdehyde (MDA) in patients with hypertension and healthy controls.
 Subjects and Methods: Whole study population included 250 hypertensive cases and 250 controls. All individuals included in the study were submitted to: Complete history and physical examinations to evaluate exclusion criteria. Serum MDA was estimated by method of Jean et al using trichloroacetic acid and thiobarbituric acid. Mean and standard deviation were calculated for serum MDA. Statistical analysis was done using SPSS no. 20 and Microsoft excel.
 Result: There was statistically higher significant increase (p value <0.001) in MDA in hypertensive cases comparison to control groups.
 Conclusion: The role of oxidation mediated tissue damage in generation of hypertension in human. Oxidative stress leads hypertension and other disease like atherosclerosis and cardiovascular diseases.
 Keywords: Malondialdehyde (MDA), Oxidative stress, Hypertension.
Highlights
Hypertension is a modern day’s epidemic, an increasingly important medical and health issue worldwide
This was observed that the average MDA concentration was found in the control group was 1.15 ± 0.26 and in the test group, it was 2.29 ± 0.38
The lipid peroxidation product like MDA levels has been measured in hypertensive patients
Summary
Hypertension is a modern day’s epidemic, an increasingly important medical and health issue worldwide. Hypertension has been recognized as the most common cardiovascular disorder and a leading cause of morbidity and mortality in both developed and developing countries[3]. The heart diseases, stroke and renal problems have caused through hypertension These pathologies are associated with vascular, functional and structure changes including endothelial dysfunction, altered contractility remodelling. Hypertension is recognized as most common cardiovascular disorder and a leading cause of morbidity and mortality worldwide. This study aims at understanding the role of oxidative stress in hypertension. Aim of the Work: The objective of this study was to determine the malondialdehyde (MDA) in patients with hypertension and healthy controls. Subjects and Methods: Whole study population included 250 hypertensive cases and 250 controls. Result: There was statistically higher significant increase (p value
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