Abstract
A comparative study of lipid profile in first attack versus relapse cases of idiopathic nephrotic syndrome in children
Highlights
Nephrotic syndrome is an important chronic disease in children characterized by heavy proteinuria, hypoalbunimea, hyperlipidemia and edema
Serum total cholesterol was measured by cholesterol oxidase phenol amino antipyrine (CHOD-PAP) method, serum triglycerides were estimated by acetyl acetone method, low density lipoproteins (LDL) cholesterol was estimated by ammonium ferrothiocyanate method, very low density lipoproteins (VLDL) cholesterol was measured by enzymatic method, Serum High density lipoproteins (HDL) Cholesterol was measured by phosphotungstate method [8,9,10]
The total serum cholesterol level (470 + 116) mg/dl was higher in relapse cases as compared to first attack group
Summary
Nephrotic syndrome is an important chronic disease in children characterized by heavy proteinuria, hypoalbunimea, hyperlipidemia and edema. One of the most pronounced secondary changes in children with nephritic syndrome is lipoprotein metabolism. High density lipoproteins (HDL) are reported to be unchanged or reduced [2]. HDL may be lost in the urine and dependent or whether or not increased synthesis can match the rate of loss, the HDL may be low or normal [1]. The pathophysiology of nephrotic dyslipoproteinemia is multifactorial, including both an increased hepatic synthesis and a diminished plasma catabolism of lipoproteins
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
