Abstract
Background: In this study, we aimed to evaluate the intra and post-operative pulse rate of ketamine-propofol mixture (Ketofol) infusion in comparison with propofol infusion.
 Methods: Prospective, randomized, double blinded controlled trial. After approval by the research ethics committee and written informed valid consent of the patients, the proposed study was carried out for a period of one year in 60 patients, in ASA-I and ASA-II patients, aged between 19 to 60 years of either sex, who were posted for laparoscopic cholecystectomy surgery at Indira Gandhi Medical College, Shimla.
 Results: HR for group K was significantly increased during intubation(89.30 ± 13.22) , 1 minute after intubation(91.30 ± 14.28), at 5minute (88.73 ± 11.94) and 10 minute(89.17 ± 12.53) in intraoperative period, every 5 minute before extubation(89.77 ± 12.82,89.93 ± 12.50, 90.13 ± 12.42),during extubation(92.10 ± 10.88) and at first 30 minutes in post operative period(88.17 ± 8.76) as compared to baseline HR(82.80 ± 10.95).HR in group P was significantly increased at 1 min after intubation(81.93 ± 10.77) , during extubation (85.80 ± 11.24) and initial 30 minute of postoperative period (82.80 ± 10.56) as compared to baseline HR(76.80 ± 12.55).
 Conclusion: HR parameter was significantly on higher side in group K during intubation, one -five -10 minutes after intubation , at 15 minutes before extubation , during extubation and at first 30 minutes of postoperative period as compared to group P where it significantly increased at one minute after intubation , during extubation and at initial 30 minutes of postoperative period when compared with their respective baselines
 Keywords: Pulse rate, Propofol, Ketamine
Highlights
Propofol is a 2, 6-diisopropylphenol which act by facilitation of inhibitory neurotransmission mediated by GABA
Background: In this study, we aimed to evaluate the intra and post-operative pulse rate of ketamine-propofol mixture (Ketofol) infusion in comparison with propofol infusion
HR for group K was significantly increased during intubation(89.30 ± 13.22), 1 minute after intubation(91.30 ± 14.28), at 5minute (88.73 ± 11.94) and 10 minute(89.17 ± 12.53) in intraoperative period, every 5 minute before extubation(89.77 ± 12.82,89.93 ± 12.50, 90.13 ± 12.42),during extubation(92.10 ± 10.88) and at first 30 minutes in post operative period(88.17 ± 8.76) as compared to baseline HR(82.80 ± 10.95).HR in group P was significantly increased at 1 min after intubation(81.93 ± 10.77), during extubation (85.80 ± 11.24) and initial 30 minute of postoperative period (82.80 ± 10.56) as compared to baseline HR(76.80 ± 12.55)
Summary
Propofol is a 2, 6-diisopropylphenol which act by facilitation of inhibitory neurotransmission mediated by GABA. We aimed to evaluate the intra and post-operative pulse rate of ketamine-propofol mixture (Ketofol) infusion in comparison with propofol infusion. Conclusion: HR parameter was significantly on higher side in group K during intubation, one -five -10 minutes after intubation , at 15 minutes before extubation , during extubation and at first 30 minutes of postoperative period as compared to group P where it significantly increased at one minute after intubation , during extubation and at initial 30 minutes of postoperative period when compared with their respective baselines Keywords: Pulse rate, Propofol, Ketamine
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