Abstract
Background: To compare the recovery in ketofol (ketamine and propofol) with propofol alone for vas in patients undergoing laparoscopic cholecystectomy
 Methods: Prospective, randomized, double blinded controlled trial. After approval by the research ethics committee and written informed valid consent of the patients, the proposed study was carried out for a period of one year in 60 patients , in ASA-I and ASA-II patients, aged between 19 to 60 years of either sex, who were posted for laproscopic cholecystectomy surgery at Indira Gandhi Medical College, Shimla.
 Results: Recovery profile was statistically significant for two groups. In group P after stopping infusion ,mean time for eye opening was 8.27 ± 1.28 which was less than group K ( 12.53 ± 1.48). Mean time of response to verbal command in group P(8.4 ± 1.19) was less than group K (12.5 ± 1.46) and mean time of extubation in group P (9.5 ± 1.25) was also less than group K (14.33 ± 1.52).
 Conclusion- Patients of Group P after stopping of infusion took less time for eye opening, obeying verbal command and also less time for extubation in comparison to group K .
 Keywords: Recovery, Propofol, Ketamine
Highlights
Ketamine is an intravenous anaesthetic developed in 1960s from its precursor phencyclidine and its mode of action is causing dissociative anaesthesia rather than generalized depression of CNS, through NMDA receptor antagonism
After approval by the research ethics committee and written informed valid consent of the patients, the proposed study was carried out for a period of one year in 60 patients, in ASA-I and ASA-II patients, aged between 19 to 60 years of either sex, who were posted for laproscopic cholecystectomy surgery at Indira Gandhi Medical College, Shimla
Recovery profile was statistically significant for two groups
Summary
Ketamine is an intravenous anaesthetic developed in 1960s from its precursor phencyclidine and its mode of action is causing dissociative anaesthesia rather than generalized depression of CNS, through NMDA receptor antagonism. Abstract Background: To compare the recovery in ketofol (ketamine and propofol) with propofol alone for vas in patients undergoing laparoscopic cholecystectomy Methods: Prospective, randomized, double blinded controlled trial. Conclusion- Patients of Group P after stopping of infusion took less time for eye opening, obeying verbal command and less time for extubation in comparison to group K .
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