Abstract
Introduction: Hemophilia is a genetic bleeding disorder caused by deficiency of clotting factor VIII (Hemophilia A) or Factor IX (Christmas disease) or Factor XI (Hemophilia C). Hemophilia is a X linked recessive trait with defective F8 an F9 genes in long arm of X chromosome. Hemophilia can also be acquired due to development of antibodies directed against the clotting factors. Aim: To compare the prevalence of Hemophilia A and Hemophilia B. Materials and Methods: The present study is done over a period of two years i.e., from 2016 to 2018. During the above period 130 cases were studied. Among these 112 cases (86.1%) were Hemophilia A and 18 cases (13.8%) were Hemophilia B. Requirement of materials: Capillary tubes, Blotting paper, Blood samples, Sprit and cotton. Results: In the present study we registered 130 cases of Hemophilia. Among these 112 cases (86.1%) were Hemophilia A and 18 cases (13.8%) were Hemophilia B.
 Keywords: Blood sample, Hemophilia A, Hemophilia B, Kadapa
Highlights
Introduction: Hemophilia is a genetic bleeding disorder caused by deficiency of clotting factor VIII (Hemophilia A) or Factor IX (Christmas disease) or Factor XI (Hemophilia C)
Haemophilia A and B are rare bleeding disorders caused by mutations in the genes encoding coagulation factor VIII (FVIII) and factor IX (FIX)
The maximum numbers of cases were seen in first decade of life in both the conditions between 0-10 year age group
Summary
Haemophilia A and B are rare bleeding disorders caused by mutations in the genes encoding coagulation factor VIII (FVIII) and factor IX (FIX). [1] Hemophilia is a X linked recessive trait with defective F8 an F9 genes in long arm of X chromosome. As per the world federation of hemophilia (WFH) 2016 global survey, India harbors the highest number (18,353) of patients with hemophilia (PwH).[2] this represents a significant under diagnosis, as with a population of 1.32 billion and a prevalence of 1/10000 male births, and the expected number of PwH in India should be approximately 1, 32, 000. This indicates that the proportion of patients diagnosed is
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