A comparative study of glycosylated hemoglobin and lipid levels in patients with diabetes mellitus type 2 and normal subjects

Abstract

Background: Uncontrolled hyperglycemia of diabetes mellitus (DM) results in impaired lipid metabolism and has been implicated in cardiovascular complications in diabetes patients. Early interventions to normalize circulating lipids have been shown to reduce cardiovascular complications and mortality. Aims and Objectives: This study was planned with the objective of comparing glycosylated hemoglobin and lipid levels in patients with DM Type 2 and normal subjects. Materials and Methods: This cross-sectional study was done at BRIMS which included 50 known Type 2 diabetic patients attending BRIMS Teaching and General Hospital and 50 age-, sex-matched healthy control. Venous blood samples were collected from all the subjects after at least 8 h fasting was collected and the serum was analyzed for various lipid parameters. Fasting blood glucose and glycated hemoglobin (HbA1c) levels were compared with lipid levels of diabetic group cases and normal subjects as controls. Results: Higher HbA1c level showed significant correlation with higher lipid levels as compared to controls. Hence, HbA1c level can be used as a marker for deranged lipid levels in Type 2 diabetic patients. Conclusion: This study is of great help in determining correlation of deranged blood glucose and lipid levels and its effect on cardiovascular health.