A comparative Study of Efficacy of Esmolol and Fentanyl For Blood Pressure and Heart Rate Attenuation During Laryngoscopy and Endotracheal Intubation

Abstract

Background: Blood pressure and heart rate elevation during laryngoscopy and tracheal intubation maycause serious medical problems ex.: patients with cardiovascular disease as well as patients with increasedintracranial pressure. Aim of study: Comparism between Fentanyl and Esmolol in attenuating blood pressureand heart rate during laryngoscope and tracheal intubation. Patients and Method:60 adult patients of bothsex, ages between (20-33) , labeled as ASA I and ASA II will undergo elective surgery, divided into twogroups, each group contain 30 patients: Esmolol Group (E) takes 0.5 mg/kg esmolol IV. And Fentanyl Group(F) takes 1 mic/kg fentanyl IV.Blood pressure and heart rate was recorded before drugs administration asbaseline reading and another reading was taken after drug administration as well as after tracheal intubation.Result: blood pressure and heart rate readings of both groups, when compared to baseline reading showsthat Regarding heart rate, there are significance differences between the two groups, in that, esmololreduce heart rate in all stages when compared to fentanyl. Regarding systolic blood pressure, both drugsreduce systolic blood pressure and there are significances in all stages, favored esmolol except in T3 due torise in sbp when using fentanyl. Regarding diastolic blood pressure, both drugs also reduce diastolic bloodpressure but there are no significances in these reading except in T3 due to esmolol reduce dpb much morethan fentanyl does. Conclusions: esmolol in a dose of 0.5mg/kg is more effective than fentanyl in a dose of1mic/kg in attenuation of hemodynamic response after endotracheal intubation.