A Comparative Study of Dynamic Light and X-ray Scatterings on Micelles of Topological Polymer Amphiphiles.

Brian J Ree,Yusuke Satoh,Moonhor Ree,Toshifumi Satoh,Takuya Isono,Kyungho Kwon,Jongchan Lee

doi:10.3390/polym10121347

Brian J Ree, Yusuke Satoh + Show 5 more

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https://doi.org/10.3390/polym10121347

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Abstract

Micelles were prepared in organic solvents by using three topological polymer amphiphiles: (i) cyclic poly(n-decyl glycidyl ether-block-2-(2-(2-methoxyethoxy)ethoxy)ethyl glycidyl ether) (c-PDGE-b-PTEGGE) and (ii) its linear analogue (l-PDGE-b-PTEGGE); (iii) linear poly(6-phosphorylcholinehexylthiopropyl glycidyl ether-block-n-dodecanoyl glycidyl ether) (l-PPCGE-b-PDDGE). For the individual micelle solutions, the size and distribution were determined by dynamic light scattering (DLS) and synchrotron X-ray scattering analyses. The synchrotron X-ray scattering analysis further found that c-PDGE-b-PTEGGE forms oblate ellipsoidal micelle in an ethanol/water mixture, l-PDGE-b-PTEGGE makes prolate ellipsoidal micelle in an ethanol/water mixture, and l-PPCGE-b-PDDGE forms cylindrical micelle in chloroform. This comparative study found that there are large differences in the size and distribution results extracted by DLS and X-ray scattering analyses. All possible factors to cause such large differences are discussed. Moreover, a better use of the DLS instrument with keeping its merits is proposed.

Highlights

Nanomaterials are widely adopted as key components in the development of new advanced technologies
The ellipsoidicity (εel = polar radius (Rp )/equatorial radius (Re )) is 0.84, which is deviated from 1. These results collectively indicate that the c-PDGE-b-PTEGGE micelle is an oblate ellipsoid in shape, which is different from a sphere assumed in the dynamic light scattering (DLS) analysis
The micelle solutions of a cyclic polymer amphiphile (c-PDGE-b-PTEGGE) and two linear polymer amphiphiles (l-PDGE-b-PTEGGE and l-PPCGE-b-PDDGE) were investigated by DLS and synchrotron

Summary

Introduction

Nanomaterials are widely adopted as key components in the development of new advanced technologies. Nanomaterials have dimensions between small molecules and bulk materials and exhibit very different properties from their counterparts. Over the wide range of nanomaterials, nanoparticles are the simplest forms of such unique materials from the point of view of nanostructures. Nanoparticle-based technologies broadly cover diverse fields, such as polymer science and technology, energy generations, chemical storages, environmental remediations, microelectronics, electro-optical and optical sciences, medical diagnostics, medical therapy, foods, cosmetics, structural materials, and so on [1,2,3,4,5,6,7]. Nanoparticles can be classified into three general categories of organic nanoparticles, inorganic nanoparticles, and organic–inorganic hybrid nanoparticles. Organic nanoparticles are subcategorized into (i) small-molecule-based micelles and vesicles, (ii) polymeric micelles and vesicles, and (iii) polymeric nanoparticles

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