Abstract
Background: The present study was conducted to compare dexmedetomidine and clonidine for attenuation of hemodynamic response during laryngoscopy and intubation. Subjects and Methods: Group I patients received 0.9% normal saline (placebo), group II patients received 0.5 µg/kg of dexmedetomidine and group III patients received 3 µg/kg of or clonidine. Each group had 15 patients. Results: The mean age in group I was 28.2 years, in group II was 32.1 years and in group III was 33.2 years, mean weight was 61.2 years, in group II was 60.4 years and in group III was 62.1 years, height was 156.2 cm, in group II was 157.1 cm and in group III was 152.8 cm. There were 8 males and 7 females in group I, 6 males and 9 females in group II and 7 males and 8 females in group III. The mean SBP (mm Hg) in group I was 121.4 and in group II was 122.6, and in group III was 127.4, DBP (mm Hg) was 76.2 in group I, 78.4 in group II and 78.2 in group III. MAP (mm Hg) was 86.7 in group I, 93.2 in group II and 92.5 in group III. HR (bpm) was 74.2 in group I, 78.4 in group II and 77.3 in group III. % oxygen saturation was 98.2in group I, 98.5 in group II and 97.9 in group III. The difference was non- significant (P> 0.05). Conclusion: Authors found that both groups were equally effective in causing attenuation of hemodynamic response to endotracheal intubation.
Highlights
Tachycardia and hypertension are exaggerated cardiovascular reflexes activated by stimuli such as endotracheal intubation and laryngoscopy due to sympathetic nervous system stimulation. [1] The aim of any anesthesia is to control these reflexes
It is evident that clonidine bring about bradycardia, hypotension, reduction in systemic vascular resistance (SVR) and cardiac output
Clonidine prohibits vasopressin and catecholamines secreation and modulates the hemodynamic changes induced by laryngoscopy and in pneumoperitoneum
Summary
Tachycardia and hypertension are exaggerated cardiovascular reflexes activated by stimuli such as endotracheal intubation and laryngoscopy due to sympathetic nervous system stimulation. [1] The aim of any anesthesia is to control these reflexes. Tachycardia and hypertension are exaggerated cardiovascular reflexes activated by stimuli such as endotracheal intubation and laryngoscopy due to sympathetic nervous system stimulation. Numerous researchers have tried various drugs for hinder the stress response to endotracheal intubation and laryngoscopy. [4] In this dose dexmedetomidine shows effective attenuation of stress response to laryngoscopy and endotracheal intubation as compared to clonidine as reported by numerous authors. The present study was conducted to compare dexmedetomidine and clonidine for attenuation of hemodynamic response during laryngoscopy and intubation. Subjects and Methods: Group I patients received 0.9% normal saline (placebo), group II patients received 0.5 μg/kg of dexmedetomidine and group III patients received 3 μg/kg of or clonidine. Conclusion: Authors found that both groups were effective in causing attenuation of hemodynamic response to endotracheal intubation
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