Abstract
In order to study the safety and efficacy of lidocaine and ropivacaine some of their actions were compared using the parameters namely local anaesthetic effect on rabbit cornea, local anaesthetic effect on the reflex movements of the nostrils of rabbit, analgesic effect on rat, cardiac effect on frog heart and the effect on the blood vessels of frog. The local anaesthetic effect on rabbit cornea and reflex movements of the nostrils of rabbit had longer duration with ropivacaine but there were differences in the onset of action. By rat tail flick method, ropivacaine proved to be more potent and longer acting in its analgesic action. Ropivacaine took longer time to produce bradycardia. There was less number of missed beats of the frog heart with ropivacaine. While lidocaine produced vasoconstriction of frog blood vessels, ropivacaine produced initial vasoconstriction followed by vasodilatation. In all the parameters used, ropivacaine proved to be more potent, longer acting and safer when compared to lidocaine.
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