Abstract
Back ground: Neonatal sepsis is one of the most important causes of morbidity and mortality in children. The incidence was 3% in intramural births, with an overall mortality rate of variation of 18.6% Aims and Objectives: To evaluate the role of blood culture, micro ESR, CBP, CRP in the diagnosis of sepsis in children. To study sensitivity, specificity, positive predictive values and negative predictive values of the above hematological parameters, either individually or in combination with diagnosis of neonatal sepsis Method: A prospective study was carried out from January 2015 to December 2015. It was cross sectional and hospital based .samples included babies having history of infective etiology with the onset within the first 28 days of birth. Result:One hundred neonatal cases of clinically suspected septicemia were included in this study. Culture positive rate was 26%. E coli was the major organism responsible for early onset of sepsis. The highest sensitivity and negative predictive value was found for septic score of more than or equal to 3 by septic scoring, I:T ratio and C- reactive protein with the highest sensitivity, micro ESR and TLC had the highest specificity.Conclusion: CRP emerged as the test with the highest sensitivity. Micro- ESR and TLC had the highest specificity.
Highlights
Neonatal sepsis in neonates is a clinical syndrome characterized by systemic sign of infection accompanied by bacteremia in the first 28 days of birth [1]
Neonatal sepsis is a complex syndrome caused by an uncontrolled systemic inflammatory response of infectious origin characterized by multiple manifestations which can result in dysfunction and failure of one or more organs and even death [2]
Among the extramural ad mission, sepsis was responsible for 39.7%; on the other hand, indiscriminative overuse of antibiotics, was hazardous for any neonatal unit which may lead to overtreatment
Summary
Neonatal sepsis in neonates is a clinical syndrome characterized by systemic sign of infection accompanied by bacteremia in the first 28 days of birth [1]. The clinicians focused on diagnostic test which has high sensitivity and high negative predictive accuracy. These are direct or indirect hematological tests [5]. A group of tests was studied to access the usefulness either singly or in combination with predicting neonatal sepsis. These tests were of total leucocytecount (TLC), Absolute neutrophil count (ANC) immature total ratio (I:T ratio) platelet count, micro ESR and CRP. Specificity, positive predictive values and negative predictive values of the above hematological parameters, either individually or in combination with diagnosis of neonatal sepsis.
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