Abstract
BackgroundCalcium is an essential mineral often taken as a daily, long-term nutritional supplement. Data suggests that once-daily dosing is important with regard to long-term compliance of both drugs and nutritional supplements.ObjectiveThis study was undertaken to compare the bioavailability of a single serving of two calcium supplements in healthy, premenopausal women.DesignA two-period, crossover bioavailability study of a single serving of calcium citrate tablets (two tablets=500 mg calcium) versus a single serving of calcium carbonate powder (one packet of powder=1,000 mg calcium) was performed in healthy women aged between 25 and 45. All subjects were on a calcium-restricted diet 7 days prior to testing and fasted for 12 h before being evaluated at 0, 1, 2, and 4 h after oral administration of the test agents. Blood measurements for total and ionized calcium and parathyroid hormone were performed and adverse events were monitored.ResultsTwenty-three women were evaluable with a mean age of 33.2±8.71. Results showed that administration of a single serving of a calcium carbonate powder resulted in greater absorption in total and ionized calcium versus a single serving of calcium citrate tablets at 4 h (4.25±0.21 vs. 4.16±0.16, p=0.001). There were minimal side effects and no reported serious adverse events.ConclusionsThis study shows that a single serving of a calcium carbonate powder is more bioavailable than a single serving of calcium citrate tablets. This may be beneficial for long-term compliance.
Highlights
Calcium is an essential mineral often taken as a daily, long-term nutritional supplement
The response curve following calcium carbonate ingestion showed a significantly greater total area under the curve (AUC) compared to the total AUC following calcium citrate tablet administration (p 00.001)
This study demonstrates that the bioavailability of a single serving of calcium carbonate powder was greater than that of a single serving of calcium citrate tablets in healthy, premenopausal women who took the study agents with a light, low-calcium meal
Summary
Calcium is an essential mineral often taken as a daily, long-term nutritional supplement. Design: A two-period, crossover bioavailability study of a single serving of calcium citrate tablets (two tablets0500 mg calcium) versus a single serving of calcium carbonate powder (one packet of powder000 mg calcium) was performed in healthy women aged between 25 and 45. Results showed that administration of a single serving of a calcium carbonate powder resulted in greater absorption in total and ionized calcium versus a single serving of calcium citrate tablets at 4 h (4.2590.21 vs 4.1690.16, p 00.001). Conclusions: This study shows that a single serving of a calcium carbonate powder is more bioavailable than a single serving of calcium citrate tablets. This may be beneficial for long-term compliance
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