A COMPARATIVE STUDY OF BIOCHEMICAL PARAMETERS AND ELECTROLYTES IN PATIENTS UNDERGOING MAJOR ABDOMINAL AND GYNAECOLOGICAL SURGERIES

Abstract

To compare Biochemical Parameters and Electrolytes in patients undergoing major abdominal & gynaecological surgeries. 60 patients of either gender of ASA grade I and II scheduled for abdominal & gynaecological surgeries in 9 months durations at AIIMS, Rishikesh were recruited for the study. Patients were divided into 2 groups. Group I was conventional (‘traditional practice’) intravenous fluid group in which balanced salt solution was given as 10 mL/kg bolus followed by 8 mL/kg/hour as infusion until the end of surgery. Group II was restrictive (‘zero balance’) intravenous fluid group in which balanced salt crystalloid at 5 mL/kg/hour as infusion was administered until the end of surgery. Parameters studied were weight, height, BMI, blood urea level, serum creatinine, serum cystatin C levels, serum sodium, serum potassium, serum chloride and eGFR level. Mean age of patients in group I was 47.7 years and in group II was 47.6 years. The mean weight was 54.7 Kgs in group I and 57. Kgs in group II. The mean height was 162.2 cms in group I and 162.6 cms in group II. The mean BMI was 15.1 kg/m2 in group I and 16.04 kg/m2 in group II. The difference found to be non- significant (P> 0.05). Restricted fluid therapy resulted in an increased risk of renal injury as depicted by higher increase in cystatin C levels and resultant fall in estimated GFR.