Abstract
Aim: to study the role of Tranexamic Acid in Controlling Blood Loss In orthopaedic surgeries.
 Material & Methods: 50 patients were included in the study during the study period. Patients were randomly allotted to 2 groups of equal participants. The first group (Group A) received Tranexamic Acid. The second group (Group B) was given Normal saline as placebo. The Total Blood Loss ( intra operative + post operative ) and Fall in Haemoglobin levels were measured post-operatively at 24 and 72 hrs of post-operative period.
 Result: The group A had showed significantly reduced total blood loss and fall in Haemoglobin, thus, requiring fewer blood transfusions. No complications were observed.
 Conclusions: the present investigation concluded that Tranexamic acid can be effective in reducing blood loss and subsequent fall in haemoglobin.
 Keywords: Tranexamic acid, Bleeding, Major Orthopaedic surgeries.
Highlights
Tranexamic acid (TXA), a synthetic derivative of lysine, competitively blocks lysine-binding sites on plasminogen, reducing the local degradation of fibrin by plasmin [4].i TXA has been used successfully to stop bleeding in multiple specialties including liver, cardiac, prostate, and dental surgeries.ii,iiiTranexamic acid (TXA) has become more commonly used within large orthopedic surgeries with expected significant
It’s widespread use has been affected by concerns regarding its safety, especially the propensity to precipitate an venous thromboembolism.ix the present study was undertaken to assess the of role of Tranexamic Acid In Controlling Blood Loss In orthopaedic surgeries
Orthopedic surgeries are associated with severe bleeding because of extensive dissections through bony and fibrotic tissue and inability to cauterize bleeding bony surfaces.x,xi Tissue and vascular damage during surgery or trauma, stimulates cascade of coagulation leading to clot formation to prevent blood loss
Summary
The group A had showed significantly reduced total blood loss and fall in Haemoglobin, requiring fewer blood transfusions.
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