Abstract
Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated in vitro and in vivo. IMR-90 cells treated with 2,2’-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage. Moreover, they could up-regulate telomerase (TE) activity, increase expressions of SIRT1, forkhead box 3a (Foxo3a), active regulator of SIRT1 (AROS) and Hu antigen R (HuR ), but decrease p53 and deleted in breast cancer 1 (DBC1) levels. However, 10 μM resveratrol in vitro and the high dose group in vivo showed relatively stronger activities of anti-aging and stimulating SIRT1 level than CR. In conclusion, resveratrol and CR showed similar anti-aging activities on SIRT1 signaling, implicating the potential of resveratrol as a CR mimetic.
Highlights
Improvements in health care have helped raise human life expectancy in recent decades, and the elderly population is increasing significantly
Rats in high dose of resveratrol + D-gal group crossed over the platform relatively much frequently than those in caloric restriction (CR) + D-gal group. These results indicated that aging model rats had impairments in spatial learning and memory, while the treatment of resveratrol or CR could restore the age-related cognitive impairment caused by D-gal administration
The results demonstrated that the expression of silencing information regulator (SIRT1) mRNA in IMR-90 cells was significantly reduced by azobis (2-amidinopropane) dihydrochloride (AAPH)
Summary
Improvements in health care have helped raise human life expectancy in recent decades, and the elderly population is increasing significantly. This still means the increasing periods of poor health or disability. CR, decreased calorie intake without malnutrition, is one of the most robust interventions that increase lifespan in model organisms from yeast to primates [2]. It could protect against the deterioration of biological functions, reducing the incidence and delaying the onset of multiple age-related diseases. Recent research is increasingly aimed at determining the feasibility and efficacy of natural and/or pharmacological CR mimetic molecules/ treatments without decreasing food consumption [5]
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