A Comparative Study of 25-Hydroxyvitamin D Level and associated Parameters in CKD and Dialysis Patients in Shiraz, Iran

Abstract

Background: Vitamin D deficiency and insufficiency generally observed in chronic kidney disease (CKD) and dialysis patients. The goal of this work was to compare the serum levels of vitamin D and its-related metabolic parameters in CKD patients and hemodialysis patients. Materials and Methods: A total of 109 dialysis patients and 99 CKD patients who had not consumed vitamin D for ≥ 1 year were enrolled in this study. 25-Hydroxy vitamin D (25-(OH) D) levels, calcium, alkaline phosphatase (ALP), hemoglobin (Hb), hematocrit (HCT), total iron-binding capacity (TIBC), parathyroid hormone (PTH) and phosphorous were evaluated in the serum of the patients. Results: 25-(OH) D levels in patients with CKD and dialysis patients were 31.73±13.34 ng/mL and 15.52±5.36 ng/mL, respectively. The levels of calcium (P=0.000), ALP (P=0.006), 25(OH) D (P=0.000), FBS (P=0.000), Hb (P=0.002), HCT (P=0.002) and TIBC (P=0.000) were significantly higher, and the levels of PTH (p=0.000) and phosphorous (P=0.000) were significantly lower in the CKD group compared to dialysis group. Conclusion: 25-(OH) D levels and its metabolic parameters except PTH and phosphorus are lower in patients on dialysis compared with the patients with CKD.