Abstract
involved The vascular endothelial growth factor (VEGF) family of angiogenic growth factors in the pathophysiology of these inconveniences . aims This study to examine Maternal serum levels of placental growth factor (PLGF) and Placental mRNA expression of VEGF, fms-like tyrosine kinase 1( FLT-1) and kinase insert domain receptor (KDR) in normotensive control (NC) women (n = 24) and women with preeclampsia (PE) (n = 50) [25 severe PE (SPE) and 25 Mild PE (MPE)]. We conducted a cross-sectional study in 50 preeclamptic women: 25women with mild PE, 25 patients with severe PE. While 24 normotensive pregnant women matched for age as a control group. we measured by real time PCR (RTPCR) Placental mRNA expression of VEGF FLT-1and KDR . and we measured Maternal serum levels of PLGF by ELISA. there was statistically significant difference between the three study groups as regards all 4 studied laboratory variables. KDR, FLT-1 and PLGF were all statistically significantly higher in control group as compared to either of the two PE groups. The mean VFGF expression was statistically higher in cases of severe PE than Mild PE, both were higher than control group (p < 0.0005).
Highlights
Pre-eclampsia affects about 7% of all pregnancies, worldwide
It is suggested that disturbed placental angiogenesis is the main characteristic of causing preeclampsia. angiogenesis formation process begins with various angiogenic factors such as vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) along with receptors associated with the membrane [5]
We undertook this study to determine the level of placental growth factor (PLGF) in maternal serum and expressions of VEGF,KDRandFlt-1 mRNA in placentae of PE in order to clarify the various discrepancies and gain further evidence for its role in Preeclampsia
Summary
Pre-eclampsia affects about 7% of all pregnancies, worldwide. It is a major cause of maternal morbidity and mortality and neonatal [1]. Current data indicates that placental ischemia& trophoblastic hypoprefusion with endothelial dysfunction as the most consistent change So far, There are many theories pathophysiological of gene expression in PE except for the decryption complete with many Muslim available to explain the different results obtained. In this way, we consider that it is useful to carry out our study using a control typical in situations in a different society to add a guide to the existing literature, Placental VEGF,KDR andFlt-1 mRNA levels have been reported to be decreased, increased or unchanged in PE cases versus uncomplicated controls. We undertook this study to determine the level of PLGF in maternal serum and expressions of VEGF,KDRandFlt-1 mRNA in placentae of PE in order to clarify the various discrepancies and gain further evidence for its role in Preeclampsia
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
